New Cyclen and L-DOPA Derivatives: Solid-Phase Synthesis, Bifunctionality, Toxicity

Author: Lili Arabuli
Co-authors: Rudolf Jezek, Tomas Macek, Petra Lovecka
Keywords: macrocyclic polyamines, 3, 4-dihydroxyphenylalanine, derivatives, synthesis, cytotoxicity
Annotation:

New small peptide functionalized cyclen and DOPA derivatives: cyclen-HisHis, cyclen-AspHis, cyclen-GluHis, DOPA-HisHis were prepared, characterized and at first stage, their cytotoxicity was studied on mammalian cells. The cytotoxicity assay showed that cyclen- and DOPA-dipeptide hybrids are non-toxic for cell line Hep G2 - ATCC® HB-8065TM (cells are derived from human liver) and HEK-293T - ATCC®CRL-11268TM (epithelial cells derived from kidney of human fetus).

Lecture files:

New Cyclen and L-DOPA Derivatives: Solid-Phase Synthesis, Bifunctionality, Toxicity [en]
ციკლენის და L-DOPA-ს ახალი ნაწარმები: მყარ-ფაზური სინთეზი, ბიფუნქციურობა, ტოქსიურობა [ka]