Separation of enantiomers of chiral sulfoxides with chloro-methyl-substitued tris-phenylcarbamate of cellulose as chiral selectors in high-performance liquid chromatography

Author: natia shashviashvili
Co-authors: Rusudan Kakava, Mari-Luiza Konjaria
Keywords: chiral selector, chiral sulfoxide, mobile phase.
Annotation:

We carried out screening of newly synthesized chiral sulfoxides on their chiral recognition ability with tris-phenylcarbamate of cellulose as chiral selectors in high-performance liquid chromatography.. By systematic variation of the chemistry and structure of chiral selectors and selectands those structural features must be prevailed which are most critical for selector-selectand binding and chiral recognition ability. In this presentation I have discussed only columns with chloro-methyl substituted-phenylcarbamates and it gave some interesting results. Our experiment was held by the help of HPLC. We have tested chiral sulfoxides. Chiral selectors: Cellulose-2 and Cellulose-4 We carried out analysis using mobile phases: methanol, ethanol, isopropanol and the mixture of n-Hexane and isopropanol. Chiral recognition ability is dramatically affected by the fine structural modification of the structure of a chiral selector or selectand.

Lecture files:

Separation of enantiomers of chiral sulfoxides with chloro-methyl-substitued tris-phenylcarbamate of cellulose as chiral selectors in high-performance liquid chromatography [en]
ქირალური სულფოქსიდების ენანტიომერების დაყოფა ცელულოზას ქლორმეთილ- ჩანაცვლებული ტრისფენილკარბამატებით მაღალეფექტურ სითხურ ქრომატოგრაფიაში [ka]