Reaction Condensation of p-Aminobenzoic Acid Ethyl Esters with D-Clucose and D-Galactose

Author: Neli Sidamonidze
Co-authors: Rusudan Vardiashvili, Maia Nucubidze
Keywords: glucose, galactose, nitrozo derivatives, p-aminobensoic acids ethyl esters
Annotation:

Synthesis ofcarbohydratederivativesandstudyof their biological activityis an importantprocess for disease prevention. Especially, carbohydrate scontaining nitrosogroup,because theyhavean effectof vasodilator; Theyplay an important role in theprocess of apoptosisandcell proliferation. Also, carbohydrate derivatives containing nitrosogroup participates in the functioningof the immune system and nervous system. The goal of present investigation consist in synthesis of N-glycosilamines containing in a Molecule nitrosogroup (N=O). Аsаn initial substance in the given work has been used the products of condensation of D-glucose (1) and D-galactose (2) from p-aminobensoic acids ethyl esters - β– N-p-aminobenzoic acids ethyl esters-D–glucopyranozylamine and β– N-p-amino-benzoic acids ethyl esters- D–galactopyranozylamine (4). By interaction of compounds (3, 4) with sodium nitrite corresponding nitrosoderivatives (5,6) has been received. Reaction proceeds according to the following scheme: The structures of obtained compounds were established by physical-chemical methods of analysis.