Studies on heterocyclic compounds chemistry Shota Samsoniya

Author: Shota Samsonia
Keywords: heterocycle, Indole, Benzimidazole, Indoloindole, spirochromene
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In order to study the influence of electronic substitutes in indolization reaction (Associate Prof. Ioseb Chikvaidze and his team) was implemented the indolization reaction by using acetophenone (1) and its (2-9) phenylhydazone derivatives in different condensational area. It is shown that the best pathway of condensation reaction is PPA and its ethyl ester. In the area of ethanol in presence of sulfuric acid or acetic acid, also a dry hydrochloride in ethanol area cause to form full resin in a reaction mixture. The new bis-spiroqromenes on the bases of benzopiroloindoles have been synthesized and studied their photochromic properties. The aim of our research work was to carry out the comparative description in photochromic properties for previously synthesized bis-spirochromenes. As a research object by us have been selected previously synthesized Fished bases bis-analogue 1,4,5,8-tetrahydro-1,1,8,8-tetramethyl-2,7-dimethyldipirolo [1,2,3-d,e:3,2,1-i,j]benzo [g]quinoxaline (4). Its further transformations have been obtained new spirochromenes. The influence of solvent on the stereo selectivity and output has been studied for Ugi reaction. The initial components as an acid were taken L-alanine, (S)-P- methoxyphenyl ethylamine, trimethylacetaldehyde and methyl-2-izocianoacetate. As the solvents were used methanol, 2,2,2-trifluorethanole and dichloromethane. It is ascertained that the target product was obtained in the area of dichloromethane, but the change of solvents do not have significant influence on the stereo selectivity. Shota Rustaveli National Science Foundation Fundamental Research Grant № FR/154 /6-420/13. The main theoretical and practical results for IV and V periods have been the synthesis of new derivatives of 5(6)-carboxy-2-(1-adamantyl)benzimidazole. Shota Rustaveli National Science Foundation grants 2016 1. PhD student grant (Marina Soselia, Supervisor prof. Shota Samsoniya), Project duration 6 months - "The research in the field of the new derivatives of benzimidazole’’ 2. Masters student grant (Bobokhidze Lia), ,, Synthesis and study of new potential DNA intercalates – 3,6-dihydropirolo [3,2: 4'5"] indole [2,3- b] quinoxalines. Grant agreement № MR_2016_1_136. Project duration 6 months; 3. Masters student grant ( Tabatadze Tamari) ,, The synthesis and study of new derivatives of 2-(1-adamantyl)-1H-5(6)-carbohydrazides. Grant agreement № MR_2016_1_135. Project duration 6 months; 4. Young Scientists’ Research Grant Call 2016 “Synthesis and study of naphthalene, thiazole and imidazole ring- containing potential bioactive polycyclic systems” Nino Nikoleishvili - Head of laboratory. Project budget (GEL) 57 000. Project duration: 01/12.2016 - 30/11/2018 5. Fundamental research grant №FR/217996/16, ’’Synthesis and study of new derivatives of adamantanbenzimidazoles and imido[4,5-e]benzoqsazoles’’ Natural Sciences, Organic chemistry, Project duration 3 years, Project budget (GEL) 210 000. Supervisor of project Zurabishvili Davit.