Influence of chronic informational stress on some behavioral and biochemical characteristics in rats

Author: George Burjanadze
Co-authors: George Burjanadze, Tamar Matitaishvili, Tamar Domianidze
Keywords: Informational stress, serotonin, ephinephrine, norephinephrine, cortikosterone
Annotation:

Stress is a common problem of modern society and the influence of several external factors on body homeostasis and depression-like behavior is very important subject of recent science, as they can have extremely negative impact on living being. The recent study was aimed to investigate the influence of stressors that have psychogenic nature on emotional level of the rats and on changes in primary messenger system. Stress was carried out in a modified shuttle chamber of active avoidance with simultaneous testing of two developed reactions, that was difficult task and the level of locomotor and exploratory activity in open-field chamber is significantly decreased too, while the fear- and anxiety-like behaviors are increased. Significant results were taken in case of various neurotransmitter (epinephrine, norepinephrine (NE) and serotonin) levels in brain, pointing out the formation of chronic stress conditions that is more clearly seen from non-different corticosterone levels in plasma, while the brain serotonin levels are markedly increased. The present study showed the influence of psychogenic stress-factors on formation of chronic mild stress conditions that are tightly connected with various psychological and behavioral disorders, as well as alterations in cellular metabolism, thus stimulating number of mental illnesses.